HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0030027 - lamellipodium
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 761
+	Hs
		925751 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		564752 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		892692 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Gg
		1154344 Q6LC82_CHICK (1-192): 1.69e-84: 249: 92.19		Q9DG15_CHICK (1-761): 2.03e-155: 471: 85.41
+	Hs
		925274 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		564527 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		545371 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		892368 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		925724 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		545454 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		POTEE_HUMAN (31-683): 6.72e-62: 227: 12.90
+	Hs
		892677 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		925736 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		925423 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		HACE1_HUMAN (134-500): 3.45e-54: 203: 15.80
+	Hs
		925551 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		925478 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		545580 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		925529 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ARAP1_HUMAN (8-205): 6.26e-49: 188: 29.35
+	Hs
		892516 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		925238 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		925204 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52