HitPredict

Interactor 1: NTRK2 (P15209)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB/GP95-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase)
Gene: NTRK2

Interactor 2: HGS (Q99LI8)
Hepatocyte growth factor-regulated tyrosine kinase substrate
Gene: HGS

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	20956301
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Mm			1 775
+	Rn
		1144355 NTRK2_RAT (1-821): 0: 683: 98.54		HGS_RAT (1-775): 4.36e-135: 420: 97.29
+	Hs
		160015 NTRK2_HUMAN (1-821): 0: 669: 93.92		HGS_HUMAN (1-775): 6.25e-136: 422: 93.31
+	Hs
		160014 NTRK3_HUMAN (10-821): 0: 567: 53.29		HGS_HUMAN (1-775): 6.25e-136: 422: 93.31
+	Hs
		159837 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		HGS_HUMAN (1-775): 6.25e-136: 422: 93.31
+	Hs
		159885 FGFR2_HUMAN (155-820): 2.71e-167: 506: 23.82		HGS_HUMAN (1-775): 6.25e-136: 422: 93.31
+	Hs
		313542 NTRK2_HUMAN (1-821): 0: 669: 93.92		ZFYV9_HUMAN (133-477): 1.34e-37: 153: 18.31
+	Hs
		277074 NTRK2_HUMAN (1-821): 0: 669: 93.92		STAM2_HUMAN (4-556): 1.17e-37: 150: 14.85
+	Hs
		1081556 NTRK3_HUMAN (10-821): 0: 567: 53.29		STAM1_HUMAN (4-158): 6.1e-41: 160: 30.97
+	Hs
		277073 NTRK3_HUMAN (10-821): 0: 567: 53.29		STAM2_HUMAN (4-556): 1.17e-37: 150: 14.85
+	Hs
		1081629 NTRK3_HUMAN (10-821): 0: 567: 53.29		GGA3_HUMAN (7-146): 1.37e-35: 146: 29.66
+	Hs
		385389 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		RUFY1_HUMAN (3-228): 5.4e-41: 162: 18.37
+	Hs
		385279 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		STAM1_HUMAN (4-158): 6.1e-41: 160: 30.97
+	Hs
		276985 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		STAM2_HUMAN (4-556): 1.17e-37: 150: 14.85
+	Hs
		385624 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		GGA3_HUMAN (7-146): 1.37e-35: 146: 29.66
+	Hs
		601538 FGFR2_HUMAN (155-820): 2.71e-167: 506: 23.82		ZFY16_HUMAN (152-477): 5.36e-41: 164: 18.09
+	Hs
		241132 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		TOM1_HUMAN (5-158): 1.69e-35: 143: 31.65
+	Hs
		313504 FGFR2_HUMAN (155-820): 2.71e-167: 506: 23.82		ZFYV9_HUMAN (133-477): 1.34e-37: 153: 18.31
+	Hs
		277002 FGFR2_HUMAN (155-820): 2.71e-167: 506: 23.82		STAM2_HUMAN (4-556): 1.17e-37: 150: 14.85
+	Rn
		88616 NTRK1_RAT (5-821): 3.22e-170: 513: 47.41		D3ZHG8_RAT (7-146): 6.69e-34: 140: 28.97
+	Hs
		385648 NTRK1_HUMAN (5-821): 2.12e-174: 524: 47.09		ANFY1_HUMAN (156-219): 1.74e-14: 79.7: 50.00