HitPredict

Interactor 1: INGR1 (P15260)
Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)
Gene: IFNGR1

Interactor 2: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	28514442, 12133952, 33961781, 21689637
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0038196 - type III interferon-mediated signaling pathway GO:0060333 - type II interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 489 Hs			1 1154
+	Hs
		616833 INLR1_HUMAN (22-447): 1.24e-85: 274: 15.83		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		238344 INGR1_HUMAN (1-489): 1.69e-169: 488: 100.00		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Hs
		616805 I10R1_HUMAN (22-429): 3.18e-67: 227: 12.71		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		616765 INAR2_HUMAN (3-466): 2.88e-60: 207: 14.96		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		616825 I20RB_HUMAN (29-292): 1.32e-51: 179: 17.79		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Mm
		546500 INGR1_MOUSE (1-489): 1.63e-148: 434: 50.61		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		565998 INAR1_HUMAN (6-368): 7.89e-41: 155: 18.35		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Mm
		69810 IL3B2_MOUSE (102-466): 6.86e-09: 60.4: 13.42		B1ASP2_MOUSE (1-1154): 0: 1021: 94.63
+	Hs
		238373 INGR2_HUMAN (27-339): 4.01e-58: 197: 16.47		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Mm
		1143570 Q63953_MOUSE (14-339): 4.44e-55: 189: 16.47		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Mm
		645934 IL3B2_MOUSE (102-466): 6.86e-09: 60.4: 13.42		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		522745 INGR1_HUMAN (1-489): 1.69e-169: 488: 100.00		SRC_HUMAN (868-1151): 7e-99: 326: 31.23
+	Dm
		53796 A1Z921_DROME (21-461): 1.41e-79: 272: 16.53		ABL_DROME (868-1154): 1.63e-94: 334: 32.99
+	Hs
		507827 INGR1_HUMAN (1-489): 1.69e-169: 488: 100.00		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		566003 INAR1_HUMAN (6-368): 7.89e-41: 155: 18.35		TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00
+	Hs
		508069 I20RB_HUMAN (29-292): 1.32e-51: 179: 17.79		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		507837 INAR1_HUMAN (6-368): 7.89e-41: 155: 18.35		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		565996 INAR1_HUMAN (6-368): 7.89e-41: 155: 18.35		FGFR2_HUMAN (580-873): 9.52e-13: 74.7: 22.74