HitPredict

Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 586 Hs			1 802
+	Hs
		607901 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		FGFR4_HUMAN (13-802): 0: 750: 100.00
+	Hs
		607883 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		FGFR4_HUMAN (13-802): 0: 750: 100.00
+	Hs
		507828 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		609192 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		FGFR3_HUMAN (5-799): 0: 712: 61.07
+	Hs
		507885 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		607900 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		FGFR4_HUMAN (13-802): 0: 750: 100.00
+	Hs
		507865 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		507884 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		546943 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		719689 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		EPHA5_HUMAN (4-771): 0: 580: 18.81
+	Hs
		665555 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		EPHB2_HUMAN (4-779): 0: 557: 17.27
+	Hs
		640048 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		EPHB2_HUMAN (4-779): 0: 557: 17.27
+	Hs
		384207 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		719722 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24
+	Hs
		384378 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		434145 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		434144 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		546957 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		TIE1_HUMAN (416-773): 1.44e-66: 242: 41.62
+	Hs
		719673 RADI_HUMAN (1-586): 7.83e-165: 484: 76.28		VGFR3_HUMAN (153-356): 9.15e-11: 67.8: 18.78
+	Hs
		640055 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		VGFR3_HUMAN (153-356): 9.15e-11: 67.8: 18.78