HitPredict

Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38280479
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 586 Hs			1 504
+	Hs
		547209 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		546967 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		640152 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		125188 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		719588 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		719410 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		505580 EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		204630 E41L2_HUMAN (2-577): 1.05e-117: 374: 19.70		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		1336123 E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		547208 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		719609 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		505678 EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		719536 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		505658 EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Dm
		1098312 MERH_DROME (3-586): 1.08e-131: 400: 40.58		KIBRA_DROME (169-320): 3.18e-32: 133: 28.29
+	Dm
		2636 MERH_DROME (3-586): 1.08e-131: 400: 40.58		A0A0B4LH59_DROME (169-320): 3.18e-32: 133: 28.29
+	Hs
		204697 E41L2_HUMAN (2-577): 1.05e-117: 374: 19.70		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		1220100 E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		299270 FARP2_HUMAN (2-548): 8.98e-114: 365: 19.42		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27