HitPredict

Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.900

The method score is based on:

Property Details
Experiments 9748260, 23414517, 12080047, 33961781
Identification Methods pull down, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EBP50_C~FERM_C
Common GO terms GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0016324 - apical plasma membrane
GO:0045296 - cadherin binding
GO:0070062 - extracellular exosome
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 586
Hs

1 337
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024