HitPredict

Interactor 1: IRF1 (P15314)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Interactor 2: IRF8 (P23611)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)
Gene: IRF8

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.910

The method score is based on:

Property Details
Experiments 12429737, 16183743, 15489234, 19487420, 10364426
Identification Methods electrophoretic mobility supershift assay, anti tag coimmunoprecipitation, bimolecular fluorescence complementation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IRF~IRF
Common GO terms GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002376 - immune system process
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
and 7 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 329
Mm

1 424
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024