HitPredict

Interactor 1: IRF1 (P15314)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Interactor 2: IL12B (P43432)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40)
Gene: IL12B

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	12517966, 19487420, 12417340
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0032735 - positive regulation of interleukin-12 production GO:0051607 - defense response to virus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 329 Mm			1 335
+	Hs
		501002 IRF1_HUMAN (1-329): 5.33e-176: 491: 84.50		IL12B_HUMAN (1-331): 5.09e-103: 307: 64.48
+	Mm
		796698 IRF4_MOUSE (7-122): 2.65e-56: 190: 41.38		IL12B_MOUSE (1-335): 7.66e-115: 337: 100.00
+	Mm
		618909 IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02		IL12B_MOUSE (1-335): 7.66e-115: 337: 100.00
+	Mm
		796692 IRF5_MOUSE (2-122): 2.48e-49: 173: 38.84		IL12B_MOUSE (1-335): 7.66e-115: 337: 100.00
+	Hs
		667349 IRF5_HUMAN (2-125): 5.71e-51: 178: 40.95		IL12B_HUMAN (1-331): 5.09e-103: 307: 64.48
+	Mm
		606540 IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02		IL6RA_MOUSE (42-328): 2.72e-61: 204: 17.35
+	Mm
		618905 IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02		CSF3R_MOUSE (7-328): 1.59e-52: 187: 12.54
+	Mm
		956338 IRF4_MOUSE (7-122): 2.65e-56: 190: 41.38		I12R2_MOUSE (33-328): 5.33e-42: 157: 14.24