Interactor 1: C1TC (P11586)
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene: MTHFD1
Interactor 2: MTHR (P42898)
Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)
Gene: MTHFR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.33 | 0.55 | 0.426 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 39571719 |
| Identification Methods | anti tag coimmunoprecipitation |
| Interaction Type | association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0001843 - neural tube closure GO:0005829 - cytosol GO:0006555 - methionine metabolic process GO:0009086 - methionine biosynthetic process GO:0035999 - tetrahydrofolate interconversion |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
