HitPredict

Interactor 1: ATF2 (P15336)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
Gene: ATF2

Interactor 2: MK10 (P53779)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Gene: MAPK10

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	11865055, 8654373
Identification Methods	enzymatic study, pull down, in-gel kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0007254 - JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 464
+	Hs
		547743 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK09_HUMAN (39-464): 1.45e-163: 469: 83.80
+	Hs
		547742 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK08_HUMAN (39-464): 5.15e-162: 465: 90.87
+	Mm
		562984 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK09_MOUSE (39-464): 8.45e-163: 467: 84.51
+	Mm
		562982 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK08_MOUSE (39-419): 3e-151: 437: 91.86
+	Hs
		173828 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK13_HUMAN (43-411): 3.49e-133: 390: 45.55
+	Hs
		547805 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK11_HUMAN (47-401): 3.53e-133: 390: 47.21
+	Hs
		547811 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK14_HUMAN (42-408): 2.57e-133: 390: 45.95
+	Hs
		568251 ATF7_HUMAN (19-500): 5.33e-94: 295: 54.29		MK08_HUMAN (39-464): 5.15e-162: 465: 90.87
+	Rn
		102456 ATF2_RAT (19-505): 5.14e-115: 350: 98.36		G3V617_RAT (42-408): 1.02e-133: 391: 45.95
+	Mm
		562973 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK14_MOUSE (42-408): 1.63e-133: 391: 45.95
+	Mm
		562985 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK11_MOUSE (47-403): 3.03e-133: 390: 46.94
+	Hs
		547709 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK03_HUMAN (58-397): 1.2e-84: 266: 42.12
+	Hs
		547713 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Hs
		568080 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK10_HUMAN (1-464): 0: 517: 100.00
+	Mm
		562980 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK03_MOUSE (58-397): 3.86e-85: 268: 42.41
+	Mm
		562975 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK01_MOUSE (53-397): 1.25e-84: 266: 42.37
+	Hs
		568074 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK09_HUMAN (39-464): 1.45e-163: 469: 83.80
+	Hs
		568073 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK08_HUMAN (39-464): 5.15e-162: 465: 90.87
+	Sp
		857024 ATF1_SCHPO (174-427): 3.42e-35: 140: 26.67		HOG1_SCHPO (47-403): 1.48e-132: 388: 41.11
+	Hs
		568066 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98