HitPredict

Interactor 1: UCHL3 (P15374)
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)
Gene: UCHL3

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	9790970, 14673145, 16503656
Identification Methods	enzymatic study, pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 230 Hs			1 81
+	Mm
		669129 UCHL3_MOUSE (1-230): 6.24e-113: 324: 98.26		NEDD8_MOUSE (1-81): 1.24e-41: 132: 98.77
+	Hs
		474910 UCHL3_HUMAN (1-230): 3.13e-113: 325: 100.00		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		548107 UCHL3_HUMAN (1-230): 3.13e-113: 325: 100.00		Q5U5U6_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		456536 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Dm
		547969 Q9XZ61_DROME (5-227): 2.21e-87: 263: 26.32		RS27A_DROME (1-77): 3.39e-36: 121: 57.14
+	Hs
		924096 BAP1_HUMAN (3-228): 3.37e-82: 261: 24.07		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		456474 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		456575 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Dm
		547926 CALYP_DROME (5-228): 4.91e-80: 249: 26.05		RS27A_DROME (1-77): 3.39e-36: 121: 57.14
+	Sp
		145594 UBLH2_SCHPO (6-229): 2.77e-85: 256: 27.07		UBL1_SCHPO (1-76): 9.64e-30: 102: 81.58
+	Sp
		145591 UBLH1_SCHPO (6-228): 3.38e-67: 208: 30.70		UBL1_SCHPO (1-76): 9.64e-30: 102: 81.58
+	Sc
		477613 UBL1_YEAST (2-227): 2.82e-52: 170: 32.22		RL40A_YEAST (1-76): 1.87e-32: 110: 55.26
+	Sc
		408320 UBL1_YEAST (2-227): 2.82e-52: 170: 32.22		RS31_YEAST (1-70): 3.03e-30: 105: 52.86
+	Sc
		715092 UBL1_YEAST (2-227): 2.82e-52: 170: 32.22		RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21