HitPredict

Interactor 1: FOSL2 (P15408)
Fos-related antigen 2 (FRA-2)
Gene: FOSL2

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 731
+	Hs
		345495 FOS_HUMAN (1-326): 3.85e-40: 146: 37.21		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		579360 ATF6A_HUMAN (10-275): 1.3e-24: 106: 13.12		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		548256 FOSL1_HUMAN (47-326): 6.16e-25: 103: 40.21		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		862626 FOSB_HUMAN (1-326): 3.81e-24: 102: 31.69		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		566776 JUNB_HUMAN (71-193): 6.45e-23: 99: 24.00		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		579219 ATF3_HUMAN (97-204): 2.3e-21: 91.3: 37.96		COP1_HUMAN (1-731): 0: 540: 100.00
+	At
		189290 HY5_ARATH (78-185): 3.1e-23: 95.9: 26.61		SPA1_ARATH (37-731): 2.69e-86: 295: 29.50
+	Hs
		571822 XBP1_HUMAN (91-323): 5.63e-28: 111: 18.46		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	At
		189255 HY5_ARATH (78-185): 3.1e-23: 95.9: 26.61		COP1_ARATH (512-730): 3.95e-30: 128: 17.67
+	At
		794472 Q1H5E5_ARATH (78-185): 3.1e-23: 95.9: 26.61		COP1_ARATH (512-730): 3.95e-30: 128: 17.67
+	At
		794482 HYH_ARATH (81-189): 5.04e-14: 70.5: 21.10		COP1_ARATH (512-730): 3.95e-30: 128: 17.67