HitPredict

Interactor 1: GCN2 (P15442)
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (General control non-derepressible protein 2) (Serine/threonine-protein kinase GCN2)
Gene: GCN2

Interactor 2: GCN2 (P15442)
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (General control non-derepressible protein 2) (Serine/threonine-protein kinase GCN2)
Gene: GCN2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.957

The method score is based on:

Property Details
Experiments 9566889, 8798780, 8200534, 24811037, 25695491, 21849502
Identification Methods affinity chromatography technology, pull down, two hybrid, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HGTP_anticodon2~HGTP_anticodon2, Pkinase~Pkinase, RWD~RWD, tRNA-synt_His~tRNA-synt_His
Common GO terms GO:0000049 - tRNA binding
GO:0000077 - DNA damage checkpoint signaling
GO:0003725 - double-stranded RNA binding
GO:0004672 - protein kinase activity
GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity
and 25 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1659
Sc

1 1659
+ Sc
+ Hs
+ Hs
+ Hs
+ Sp
+ At
+ Gm
+ At
+ At
+ At
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024