HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: PRLR (P16471)
Prolactin receptor (PRL-R)
Gene: PRLR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	7768923, 11328862
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 845 Hs			1 622
+	Hs
		560471 VAV2_HUMAN (1-839): 0: 562: 47.14		PRLR_HUMAN (1-622): 7.24e-167: 491: 100.00
+	Hs
		548635 VAV_HUMAN (1-845): 0: 641: 100.00		EPOR_HUMAN (31-449): 3.13e-49: 180: 18.59
+	Hs
		548653 VAV_HUMAN (1-845): 0: 641: 100.00		IL6RB_HUMAN (46-322): 9.4e-28: 121: 14.80
+	Hs
		855777 VAV2_HUMAN (1-839): 0: 562: 47.14		EPHA4_HUMAN (27-330): 7.92e-52: 194: 12.38
+	Hs
		855816 VAV2_HUMAN (1-839): 0: 562: 47.14		TITIN_HUMAN (275-597): 9.89e-10: 64.3: 11.01
+	Hs
		872675 NGEF_HUMAN (44-525): 4.65e-71: 250: 17.09		EPHA4_HUMAN (27-330): 7.92e-52: 194: 12.38
+	Hs
		279867 TRIO_HUMAN (182-669): 1.27e-49: 193: 14.54		EPHA7_HUMAN (27-330): 1.29e-56: 208: 15.12
+	Hs
		279833 TRIO_HUMAN (182-669): 1.27e-49: 193: 14.54		PTPRF_HUMAN (22-257): 4.3e-28: 122: 18.14
+	Hs
		540459 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45
+	Hs
		500956 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		GHR_HUMAN (31-566): 5.33e-64: 224: 22.45
+	Hs
		581163 GRAP_HUMAN (617-838): 4.62e-28: 114: 34.07		EPOR_HUMAN (31-449): 3.13e-49: 180: 18.59
+	Hs
		279839 TRIO_HUMAN (182-669): 1.27e-49: 193: 14.54		PTPRD_HUMAN (24-491): 1.02e-17: 89.7: 11.74
+	Mm
		872621 GRB2_MOUSE (787-838): 7.83e-15: 76.3: 48.08		EPHB2_MOUSE (28-330): 1.96e-53: 199: 12.58
+	Hs
		562545 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		IL7RA_HUMAN (108-440): 8.92e-55: 194: 19.73
+	Rn
		70090 D3ZWV8_RAT (188-378): 3.18e-14: 79.3: 28.57		B2B9B0_RAT (28-330): 2.76e-50: 189: 12.58
+	Hs
		279860 TRIO_HUMAN (182-669): 1.27e-49: 193: 14.54		PTPRS_HUMAN (24-457): 6.87e-13: 74.3: 12.64
+	Mm
		770716 GRB2_MOUSE (787-838): 7.83e-15: 76.3: 48.08		CSF3R_MOUSE (14-238): 3.97e-51: 191: 24.05
+	Mm
		540268 GRB2_MOUSE (787-838): 7.83e-15: 76.3: 48.08		EPOR_MOUSE (32-412): 5.9e-49: 180: 19.24
+	Hs
		581157 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		EPOR_HUMAN (31-449): 3.13e-49: 180: 18.59
+	Hs
		645942 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		CNTFR_HUMAN (8-235): 3.21e-47: 172: 22.18