HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.936

Property	Details
Experiments	9047237, 8703037, 19635790, 10347175, 8673706, 21725281
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	C1_1~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction GO:0006955 - immune response GO:0035556 - intracellular signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 845 Hs			1 533
+	Mm
		654983 VAV_MOUSE (1-845): 0: 634: 93.14		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		548737 VAV_HUMAN (1-845): 0: 641: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		1261030 VAV3_HUMAN (1-840): 0: 601: 57.31		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Gg
		1257382 Q8UUX6_CHICK (1-840): 0: 597: 57.03		BLNK_CHICK (52-520): 2.03e-31: 129: 21.42
+	Hs
		855816 VAV2_HUMAN (1-839): 0: 562: 47.14		TITIN_HUMAN (174-447): 1.53e-11: 69.6: 10.64
+	Ce
		136804 VAV_CAEEL (2-842): 7.35e-123: 396: 22.68		UNC89_CAEEL (18-449): 2.26e-18: 91.6: 9.75
+	Mm
		1141385 GRAP_MOUSE (617-838): 2.61e-27: 112: 32.30		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		924534 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		1141127 GRB2_MOUSE (787-838): 7.83e-15: 76.3: 48.08		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		924670 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		924727 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Mm
		222321 GRB2_MOUSE (787-838): 7.83e-15: 76.3: 48.08		O54737_MOUSE (52-523): 4.71e-33: 134: 19.88
+	Hs
		924632 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		203218 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		554292 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		924760 GRB2_HUMAN (787-838): 7.33e-15: 76.3: 48.08		PRG4_HUMAN (53-459): 6.87e-09: 60.8: 10.39