HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10867021
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007229 - integrin-mediated signaling pathway GO:0048010 - vascular endothelial growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 845 Hs			1 1009
+	Hs
		337333 VAV_HUMAN (1-845): 0: 641: 100.00		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		548711 VAV_HUMAN (1-845): 0: 641: 100.00		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		383580 VAV_HUMAN (1-845): 0: 641: 100.00		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411580 VAV_HUMAN (1-845): 0: 641: 100.00		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		1071026 VAV3_HUMAN (1-840): 0: 601: 57.31		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		548654 VAV_HUMAN (1-845): 0: 641: 100.00		TEC_HUMAN (301-688): 9.38e-118: 377: 26.46
+	Hs
		384022 VAV3_HUMAN (1-840): 0: 601: 57.31		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411981 VAV_HUMAN (1-845): 0: 641: 100.00		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		507829 VAV_HUMAN (1-845): 0: 641: 100.00		FGFR1_HUMAN (360-728): 4.75e-110: 362: 29.08
+	Hs
		383927 Q96D37_HUMAN (66-845): 0: 588: 99.62		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		855797 VAV2_HUMAN (1-839): 0: 562: 47.14		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		383705 VAV2_HUMAN (1-839): 0: 562: 47.14		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		412098 VAV2_HUMAN (1-839): 0: 562: 47.14		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		855777 VAV2_HUMAN (1-839): 0: 562: 47.14		EPHA4_HUMAN (388-709): 3.79e-108: 361: 35.89
+	Hs
		411673 FGD1_HUMAN (50-683): 3.96e-74: 263: 15.05		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		412357 ECT2_HUMAN (83-631): 2.68e-76: 268: 16.55		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		224698 KALRN_HUMAN (140-667): 4.19e-64: 237: 15.91		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		442854 NGEF_HUMAN (44-525): 4.65e-71: 250: 17.09		HCK_HUMAN (286-694): 3.05e-116: 369: 30.10
+	Hs
		872675 NGEF_HUMAN (44-525): 4.65e-71: 250: 17.09		EPHA4_HUMAN (388-709): 3.79e-108: 361: 35.89
+	Hs
		609419 NGEF_HUMAN (44-525): 4.65e-71: 250: 17.09		FGFR3_HUMAN (351-683): 4.17e-109: 359: 31.39