HitPredict

Interactor 1: CSF2R (P15509)
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116)
Gene: CSF2RA

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12538575, 17474147
Identification Methods	affinity chromatography technology, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 724
+	Hs
		655380 EPHA7_HUMAN (9-392): 7.26e-51: 185: 11.25		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		500948 GHR_HUMAN (107-382): 6.18e-50: 180: 16.61		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655222 EPHB2_HUMAN (7-349): 8.18e-47: 173: 10.70		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655284 EPHA5_HUMAN (9-344): 3.39e-46: 171: 11.60		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655220 EPHA3_HUMAN (7-321): 2.01e-44: 166: 9.88		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		581150 EPOR_HUMAN (95-380): 2.1e-43: 160: 14.57		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		540266 EPOR_MOUSE (97-380): 4.24e-44: 161: 14.38		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		562513 IL7RA_HUMAN (91-386): 3.37e-41: 153: 15.74		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		643058 IL2RG_MOUSE (123-388): 2.67e-43: 156: 18.61		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		655246 IL6RB_HUMAN (35-397): 7.41e-25: 109: 12.33		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129297 EPHA7_HUMAN (9-392): 7.26e-51: 185: 11.25		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129180 GHR_HUMAN (107-382): 6.18e-50: 180: 16.61		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129211 EPHB2_HUMAN (7-349): 8.18e-47: 173: 10.70		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129252 EPHA5_HUMAN (9-344): 3.39e-46: 171: 11.60		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129209 EPHA3_HUMAN (7-321): 2.01e-44: 166: 9.88		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		872468 EPHA5_HUMAN (9-344): 3.39e-46: 171: 11.60		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		64660 EPHB2_HUMAN (7-349): 8.18e-47: 173: 10.70		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		253355 EPHA7_HUMAN (9-392): 7.26e-51: 185: 11.25		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		253317 EPHB2_HUMAN (7-349): 8.18e-47: 173: 10.70		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		433265 EPHB2_HUMAN (7-349): 8.18e-47: 173: 10.70		YES_HUMAN (568-724): 2.15e-31: 131: 20.61