HitPredict

Interactor 1: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Interactor 2: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 25416956, 16189514, 25910212, 32296183, 11835509, 31980649, 17314099, 18815136, 10602478, 25502805, 31515488, unassigned1304
Identification Methods two hybrid, x-ray crystallography, affinity chromatography technology, enzymatic study, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid, pull down, protein kinase assay and 2 others

more...
Interaction Type direct interaction, association, physical association, phosphorylation reaction, phosphotransfer reaction

The annotation score is based on:

Property Details
Interacting Pfam domains NDK~NDK
Common GO terms GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004536 - DNA nuclease activity
GO:0004550 - nucleoside diphosphate kinase activity
GO:0005524 - ATP binding
and 22 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 152
Hs

1 152
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024