HitPredict

Interactor 1: VEGFA (P15692)
Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]
Gene: VEGFA

Interactor 2: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.980

The method score is based on:

Property Details
Experiments 35874709, 28514442, 18593464, 33961781, 21939755, 8621427, 8631822, 21596751, 9393862, 1312256, 10543948, 20660291
Identification Methods pull down, affinity chromatography technology, unspecified method, biochemical, genetic interference, biophysical, coimmunoprecipitation, solid phase assay, x-ray crystallography, anti tag coimmunoprecipitation and 2 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PDGF~ig, Ig_3~PDGF
Common GO terms GO:0001525 - angiogenesis
GO:0005615 - extracellular space
GO:0008284 - positive regulation of cell population proliferation
GO:0030335 - positive regulation of cell migration
GO:0035924 - cellular response to vascular endothelial growth factor stimulus
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024