HitPredict - High confidence protein-protein interactions

Interactor 1: VEGFA (P15692)
Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]
Gene: VEGFA

Interactor 2: VEGFB (P49765)
Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
Gene: VEGFB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDGF~PDGF
Common GO terms	GO:0001666 - response to hypoxia GO:0001934 - positive regulation of protein phosphorylation GO:0001938 - positive regulation of endothelial cell proliferation GO:0002040 - sprouting angiogenesis GO:0005576 - extracellular region and 19 others more... GO:0005615 - extracellular space GO:0008083 - growth factor activity GO:0008201 - heparin binding GO:0010629 - negative regulation of gene expression GO:0016020 - membrane GO:0031093 - platelet alpha granule lumen GO:0038084 - vascular endothelial growth factor signaling pathway GO:0042056 - chemoattractant activity GO:0043066 - negative regulation of apoptotic process GO:0043183 - vascular endothelial growth factor receptor 1 binding GO:0043184 - vascular endothelial growth factor receptor 2 binding GO:0045766 - positive regulation of angiogenesis GO:0048010 - vascular endothelial growth factor receptor signaling pathway GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation GO:0050930 - induction of positive chemotaxis GO:0051781 - positive regulation of cell division GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0060754 - positive regulation of mast cell chemotaxis GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	395
Hs

1	207

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Last updated: 15 Jul 2024