HitPredict

Interactor 1: UBC4 (P15731)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Interactor 2: HEL1 (P36113)
E3 ubiquitin-protein ligase HEL1 (EC 2.3.2.31) (Histone E3 ligase 1) (RING-type E3 ubiquitin transferase HEL1)
Gene: HEL1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	22570702
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	IBR~UQ_con, UQ_con~zf-C3HC4
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 148 Sc			1 551
+	Hs
		849498 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		ARI1_HUMAN (83-551): 9.33e-158: 463: 29.44
+	Hs
		312679 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		ARI2_HUMAN (43-540): 2.28e-137: 409: 23.69
+	Hs
		312520 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		ARI2_HUMAN (43-540): 2.28e-137: 409: 23.69
+	Hs
		312553 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		ARI2_HUMAN (43-540): 2.28e-137: 409: 23.69
+	Hs
		919757 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		RN19B_HUMAN (161-397): 9.4e-68: 234: 23.41
+	Hs
		919876 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		RN19A_HUMAN (131-397): 2.06e-65: 229: 20.14
+	Hs
		1347205 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RN216_HUMAN (77-444): 1.93e-54: 199: 13.73
+	Hs
		849460 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RN216_HUMAN (77-444): 1.93e-54: 199: 13.73
+	Hs
		1356055 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		TRIM1_HUMAN (150-468): 6.07e-54: 196: 13.51
+	Hs
		919878 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		RN216_HUMAN (77-444): 1.93e-54: 199: 13.73
+	Hs
		849480 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		TRIM1_HUMAN (150-468): 6.07e-54: 196: 13.51
+	Hs
		1151762 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		Q6GX22_HUMAN (170-468): 2.52e-51: 188: 13.72
+	Hs
		1354303 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RNF14_HUMAN (144-373): 3.89e-49: 178: 22.35
+	Hs
		849474 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RNF14_HUMAN (144-373): 3.89e-49: 178: 22.35
+	Hs
		919891 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		RNF14_HUMAN (144-373): 3.89e-49: 178: 22.35
+	Hs
		842095 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		R144A_HUMAN (178-373): 6.99e-50: 175: 23.30
+	Hs
		229121 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		PRKN_HUMAN (142-376): 4.79e-47: 172: 18.56
+	Hs
		842104 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		R144A_HUMAN (178-373): 6.99e-50: 175: 23.30
+	Hs
		226914 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		PRKN_HUMAN (142-376): 4.79e-47: 172: 18.56
+	Hs
		227093 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		PRKN_HUMAN (142-376): 4.79e-47: 172: 18.56