HitPredict

Interactor 1: UBC4 (P15731)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Interactor 2: CUL8 (P47050)
Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
Gene: RTT101

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18704118
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 148 Sc			1 842
+	Hs
		895792 UB2D3_HUMAN (2-148): 4.59e-81: 236: 78.91		CUL4B_HUMAN (305-842): 1e-154: 477: 16.70
+	Hs
		828994 UBE2A_HUMAN (3-145): 9.11e-71: 211: 37.06		CUL4B_HUMAN (305-842): 1e-154: 477: 16.70
+	Hs
		849326 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		CUL4A_HUMAN (305-842): 1.6e-142: 441: 14.16
+	Hs
		895791 UB2D3_HUMAN (2-148): 4.59e-81: 236: 78.91		CUL4A_HUMAN (305-842): 1.6e-142: 441: 14.16
+	Hs
		1043149 UB2E3_HUMAN (2-147): 2.67e-75: 224: 64.38		CUL4A_HUMAN (305-842): 1.6e-142: 441: 14.16
+	Hs
		849325 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		919724 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		1042304 UB2E2_HUMAN (2-147): 1.04e-75: 225: 64.38		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		1042223 UB2E3_HUMAN (2-147): 2.67e-75: 224: 64.38		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Sp
		804458 UBC4_SCHPO (2-148): 1.77e-80: 235: 82.31		CUL3_SCHPO (297-842): 7.7e-127: 401: 14.29
+	Hs
		851812 UB2E1_HUMAN (2-147): 1.08e-73: 219: 64.38		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		896438 UBE2N_HUMAN (4-148): 7.89e-70: 208: 46.90		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		1041136 UB2E3_HUMAN (2-147): 2.67e-75: 224: 64.38		CUL1_HUMAN (305-842): 2.43e-124: 394: 15.71
+	Dm
		639393 UBCD1_DROME (2-148): 1.08e-81: 238: 79.59		CUL1_DROME (305-842): 2.02e-117: 375: 13.87
+	Hs
		849324 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		CUL2_HUMAN (304-842): 1.13e-110: 357: 13.20
+	Hs
		895790 UB2D3_HUMAN (2-148): 4.59e-81: 236: 78.91		CUL2_HUMAN (304-842): 1.13e-110: 357: 13.20
+	At
		1228143 COP10_ARATH (2-147): 1.02e-53: 169: 53.43		CUL4_ARATH (305-842): 1.89e-123: 392: 14.16