HitPredict

Interactor 1: UBC4 (P15731)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Interactor 2: HUL5 (P53119)
E3 ubiquitin-protein ligase HUL5 (EC 2.3.2.26)
Gene: HUL5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21983566
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0071629 - cytoplasm protein quality control by the ubiquitin-proteasome system
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 148 Sc			1 910
+	Sc
		549861 UBC5_YEAST (1-148): 6.96e-82: 239: 92.57		HUL5_YEAST (1-910): 0: 1253: 100.00
+	Hs
		125808 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		WWP2_HUMAN (378-908): 0: 548: 21.63
+	Hs
		125262 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		WWP2_HUMAN (378-908): 0: 548: 21.63
+	Hs
		125335 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		WWP2_HUMAN (378-908): 0: 548: 21.63
+	Hs
		1294888 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		ITCH_HUMAN (380-908): 4.16e-180: 545: 22.46
+	Hs
		849411 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		ITCH_HUMAN (380-908): 4.16e-180: 545: 22.46
+	Hs
		849444 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		WWP1_HUMAN (385-908): 4.65e-172: 525: 20.63
+	Hs
		849416 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		NED4L_HUMAN (424-908): 4.67e-169: 519: 23.77
+	Hs
		849334 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		UBE3C_HUMAN (343-910): 1.06e-167: 518: 32.01
+	Hs
		919732 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		UBE3C_HUMAN (343-910): 1.06e-167: 518: 32.01
+	Hs
		808052 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		NEDD4_HUMAN (392-908): 3.86e-162: 510: 22.44
+	Hs
		808078 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		NEDD4_HUMAN (392-908): 3.86e-162: 510: 22.44
+	Sc
		549815 UBC4_YEAST (1-148): 2.13e-82: 240: 100.00		RSP5_YEAST (446-908): 1.23e-164: 502: 25.00
+	Sc
		549857 UBC5_YEAST (1-148): 6.96e-82: 239: 92.57		RSP5_YEAST (446-908): 1.23e-164: 502: 25.00
+	Hs
		849451 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		SMUF2_HUMAN (403-907): 3.46e-164: 499: 20.92
+	Hs
		849353 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		HUWE1_HUMAN (384-910): 1.41e-149: 491: 27.16
+	Hs
		849452 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		SMUF1_HUMAN (406-907): 1.27e-159: 487: 20.99
+	Hs
		849311 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		UBE3A_HUMAN (558-909): 1.24e-39: 160: 32.87
+	Hs
		919710 UB2D2_HUMAN (2-148): 3.09e-82: 239: 78.91		UBE3A_HUMAN (558-909): 1.24e-39: 160: 32.87
+	Hs
		849351 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		HECW1_HUMAN (550-909): 8.28e-37: 152: 32.44