HitPredict

Interactor 1: UBC4 (P15731)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Interactor 2: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	14593114, 11146622
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 148 Sc			1 551
+	Hs
		1356614 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		AMFR_HUMAN (41-477): 3.96e-54: 195: 15.82
+	Hs
		849484 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		AMFR_HUMAN (41-477): 3.96e-54: 195: 15.82
+	Hs
		1148281 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RNF43_HUMAN (221-519): 3.36e-35: 142: 11.44
+	Hs
		849341 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RNF43_HUMAN (221-519): 3.36e-35: 142: 11.44
+	Sc
		549807 UBC4_YEAST (1-148): 2.13e-82: 240: 100.00		TUL1_YEAST (79-405): 9.21e-31: 129: 12.53
+	Hs
		1204871 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		GOLI_HUMAN (273-483): 1.19e-30: 125: 17.84
+	Hs
		1356934 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RN150_HUMAN (272-509): 1.72e-30: 125: 14.23
+	At
		715137 UBC9_ARATH (2-148): 2.68e-82: 240: 76.87		RNG1L_ARATH (209-434): 1.38e-31: 126: 16.37
+	Hs
		849359 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		GOLI_HUMAN (273-483): 1.19e-30: 125: 17.84
+	Hs
		849485 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RN150_HUMAN (272-509): 1.72e-30: 125: 14.23
+	Hs
		1332598 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RN167_HUMAN (216-451): 8.71e-29: 119: 14.88
+	Zm
		74334 B4FC97_MAIZE (2-148): 5.17e-83: 241: 80.27		B6U926_MAIZE (297-498): 2.83e-28: 118: 14.85
+	Zm
		79637 B6SZE0_MAIZE (2-148): 5.59e-83: 241: 78.91		B6U926_MAIZE (297-498): 2.83e-28: 118: 14.85
+	Hs
		849446 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RN167_HUMAN (216-451): 8.71e-29: 119: 14.88
+	Hs
		1377467 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RN115_HUMAN (308-420): 4.54e-18: 87: 22.58
+	Hs
		849497 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RN115_HUMAN (308-420): 4.54e-18: 87: 22.58
+	Hs
		1313520 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		RN126_HUMAN (308-417): 3e-15: 78.9: 17.65
+	Hs
		1205159 UB2D4_HUMAN (2-148): 4.02e-83: 242: 79.59		DZIP3_HUMAN (348-421): 3.84e-14: 77.7: 24.32
+	Hs
		849428 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		RN126_HUMAN (308-417): 3e-15: 78.9: 17.65
+	Hs
		849362 UB2D1_HUMAN (2-148): 1.97e-82: 240: 78.23		DZIP3_HUMAN (348-421): 3.84e-14: 77.7: 24.32