HitPredict

Interactor 1: UBC5 (P15732)
Ubiquitin-conjugating enzyme E2-16 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 5) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)
Gene: UBC5

Interactor 2: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.942

Property	Details
Experiments	17418786, 12654912, 19364824, 28069708, 21685393, 19920177
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 148 Sc			1 809
+	Sc
		549815 UBC4_YEAST (1-148): 3.78e-81: 237: 92.57		RSP5_YEAST (1-809): 0: 825: 100.00
+	Hs
		1294888 UB2D4_HUMAN (2-148): 1.42e-81: 238: 78.91		ITCH_HUMAN (1-809): 0: 727: 34.62
+	Hs
		849411 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		ITCH_HUMAN (1-809): 0: 727: 34.62
+	Hs
		919827 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		ITCH_HUMAN (1-809): 0: 727: 34.62
+	Hs
		849452 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		SMUF1_HUMAN (4-809): 0: 701: 36.64
+	Hs
		849444 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		WWP1_HUMAN (108-809): 0: 690: 40.33
+	Hs
		919860 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		WWP1_HUMAN (108-809): 0: 690: 40.33
+	Hs
		125808 UB2D4_HUMAN (2-148): 1.42e-81: 238: 78.91		WWP2_HUMAN (100-809): 0: 684: 40.81
+	Hs
		125262 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		WWP2_HUMAN (100-809): 0: 684: 40.81
+	Hs
		125335 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		WWP2_HUMAN (100-809): 0: 684: 40.81
+	Hs
		849416 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		NED4L_HUMAN (145-806): 0: 676: 43.87
+	Hs
		919834 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		NED4L_HUMAN (145-806): 0: 676: 43.87
+	Hs
		808052 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		NEDD4_HUMAN (102-807): 0: 668: 39.67
+	Hs
		808078 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		NEDD4_HUMAN (102-807): 0: 668: 39.67
+	Hs
		849451 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		SMUF2_HUMAN (230-809): 0: 640: 42.86
+	Hs
		919867 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		SMUF2_HUMAN (230-809): 0: 640: 42.86
+	Hs
		849353 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		HUWE1_HUMAN (252-808): 3.56e-167: 539: 31.78
+	Hs
		919765 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		HUWE1_HUMAN (252-808): 3.56e-167: 539: 31.78
+	Hs
		849351 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		HECW1_HUMAN (11-358): 4.09e-09: 62.5: 13.48
+	Hs
		919762 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		HECW1_HUMAN (11-358): 4.09e-09: 62.5: 13.48