HitPredict

Interactor 1: UBC5 (P15732)
Ubiquitin-conjugating enzyme E2-16 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 5) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)
Gene: UBC5

Interactor 2: RBX1 (Q08273)
RING-box protein HRT1 (RING-box protein 1) (E3 ubiquitin-protein ligase complex SCF subunit HRT1) (High level expression reduces Ty3 transposition protein 1) (Regulator of cullins protein 1)
Gene: HRT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	19920177, 15960978
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-rbx1
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 148 Sc			1 121
+	Sc
		549843 UBC4_YEAST (1-148): 3.78e-81: 237: 92.57		RBX1_YEAST (1-121): 4.52e-48: 151: 100.00
+	Hs
		921482 UB2D4_HUMAN (2-148): 1.42e-81: 238: 78.91		RBX1_HUMAN (24-120): 5.3e-44: 140: 60.83
+	Ce
		715111 UBC2_CAEEL (2-148): 1.17e-80: 236: 78.91		RBX1_CAEEL (14-120): 1.24e-43: 140: 55.14
+	Hs
		849303 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		RBX1_HUMAN (24-120): 5.3e-44: 140: 60.83
+	Mm
		895979 UB2D1_MOUSE (2-148): 6.69e-81: 236: 78.91		RBX1_MOUSE (24-120): 5.3e-44: 140: 60.83
+	Hs
		919703 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		RBX1_HUMAN (24-120): 5.3e-44: 140: 60.83
+	Mm
		919923 UB2D2_MOUSE (2-148): 1.51e-80: 235: 78.91		RBX1_MOUSE (24-120): 5.3e-44: 140: 60.83
+	Hs
		1354003 UB2D4_HUMAN (2-148): 1.42e-81: 238: 78.91		RBX2_HUMAN (11-121): 1.83e-33: 114: 41.44
+	Hs
		849472 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		RBX2_HUMAN (11-121): 1.83e-33: 114: 41.44
+	Hs
		849463 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		APC11_HUMAN (34-118): 2.95e-28: 100: 34.09
+	Hs
		919882 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		APC11_HUMAN (34-118): 2.95e-28: 100: 34.09
+	Sc
		549847 UBC4_YEAST (1-148): 3.78e-81: 237: 92.57		APC11_YEAST (34-118): 8.09e-24: 91.5: 27.36
+	Sc
		549868 UBC5_YEAST (1-148): 1.51e-80: 235: 100.00		APC11_YEAST (34-118): 8.09e-24: 91.5: 27.36
+	Ce
		715108 UBC2_CAEEL (2-148): 1.17e-80: 236: 78.91		APC11_CAEEL (34-118): 1.64e-23: 89.9: 32.97
+	Hs
		1346940 UB2D4_HUMAN (2-148): 1.42e-81: 238: 78.91		RNF12_HUMAN (15-112): 2.93e-12: 63.8: 15.00
+	Hs
		919766 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		SYVN1_HUMAN (48-113): 4.51e-13: 66.1: 21.21
+	Hs
		1356614 UB2D4_HUMAN (2-148): 1.42e-81: 238: 78.91		AMFR_HUMAN (50-121): 1.2e-11: 61.8: 22.22
+	Hs
		849459 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		RNF12_HUMAN (15-112): 2.93e-12: 63.8: 15.00
+	Hs
		919877 UB2D2_HUMAN (2-148): 1.51e-80: 235: 78.91		RNF12_HUMAN (15-112): 2.93e-12: 63.8: 15.00
+	Hs
		849484 UB2D1_HUMAN (2-148): 6.69e-81: 236: 78.91		AMFR_HUMAN (50-121): 1.2e-11: 61.8: 22.22