HitPredict

Interactor 1: KCC2D (P15791)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: Camk2d

Interactor 2: NMDE2 (Q00960)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)
Gene: Grin2b

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	12147342, 16120608
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001666 - response to hypoxia GO:0005737 - cytoplasm GO:0006816 - calcium ion transport GO:0043005 - neuron projection GO:0043025 - neuronal cell body
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 533 Rn			1 1482
+	Mm
		659449 KCC2B_MOUSE (1-512): 0: 576: 77.31		NMDE2_MOUSE (1-1482): 0: 1846: 99.46
+	Rn
		506719 KCC2A_RAT (1-511): 0: 551: 80.82		NMDE2_RAT (1-1482): 0: 1852: 100.00
+	Mm
		515226 KCC2A_MOUSE (1-511): 0: 551: 80.82		NMDE2_MOUSE (1-1482): 0: 1846: 99.46
+	Hs
		1028136 KCC2G_HUMAN (1-512): 0: 554: 77.06		NMDE2_HUMAN (1-1482): 0: 1828: 98.38
+	Hs
		1028155 KCC2A_HUMAN (1-511): 0: 551: 80.82		NMDE2_HUMAN (1-1482): 0: 1828: 98.38
+	Rn
		550160 KCC2D_RAT (1-533): 0: 643: 100.00		NMDE1_RAT (9-1482): 0: 1498: 52.31
+	Rn
		506718 KCC2A_RAT (1-511): 0: 551: 80.82		NMDE1_RAT (9-1482): 0: 1498: 52.31
+	Mm
		659444 KCC2B_MOUSE (1-512): 0: 576: 77.31		NMDZ1_MOUSE (14-940): 0: 675: 24.04
+	Rn
		506693 KCC2A_RAT (1-511): 0: 551: 80.82		GRIA1_RAT (11-901): 0: 683: 19.81
+	Hs
		786716 KCC2A_HUMAN (1-511): 0: 551: 80.82		GRIA1_HUMAN (16-901): 0: 682: 19.90
+	Mm
		515217 KCC2A_MOUSE (1-511): 0: 551: 80.82		NMDZ1_MOUSE (14-940): 0: 675: 24.04
+	Hs
		984259 KCC2G_HUMAN (1-512): 0: 554: 77.06		NMDZ1_HUMAN (13-940): 0: 672: 24.12
+	Hs
		984288 KCC2A_HUMAN (1-511): 0: 551: 80.82		NMDZ1_HUMAN (13-940): 0: 672: 24.12
+	Rn
		514948 KCC2G_RAT (1-512): 0: 567: 78.94		GRIA4_RAT (16-852): 0: 644: 20.89
+	Hs
		816227 KCC2A_HUMAN (1-511): 0: 551: 80.82		GRIA4_HUMAN (16-852): 0: 647: 20.89