HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: MSH3 (P25336)
DNA mismatch repair protein MSH3 (Mismatch-binding protein) (MBP) (MutS protein homolog 3)
Gene: MSH3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.623

Property	Details
Experiments	20967232, 12239216, 11005803
Identification Methods	two hybrid, affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000710 - meiotic mismatch repair GO:0005634 - nucleus GO:0006298 - mismatch repair
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 1018
+	Hs
		517148 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		MSH6_HUMAN (22-1015): 0: 873: 21.22
+	Sp
		251607 PCNA_SCHPO (1-258): 9.83e-103: 300: 44.57		MSH6_SCHPO (49-999): 0: 818: 21.79
+	Hs
		517045 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		MSH3_HUMAN (31-1005): 0: 795: 29.95
+	Hs
		517121 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		MSH2_HUMAN (121-1014): 0: 772: 22.01
+	Hs
		238262 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		MSH6_HUMAN (22-1015): 0: 873: 21.22
+	Sc
		550570 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		MSH6_YEAST (35-982): 0: 767: 22.41
+	Hs
		238253 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		MSH3_HUMAN (31-1005): 0: 795: 29.95
+	Hs
		238260 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		MSH2_HUMAN (121-1014): 0: 772: 22.01
+	Sc
		550522 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		MSH2_YEAST (135-992): 0: 666: 21.14