HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: RFC5 (P38251)
Replication factor C subunit 5 (Replication factor C5) (Activator 1 40 kDa subunit)
Gene: RFC5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	8995429, 25450506, 16608854, 20455582, 22197374
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006272 - leading strand elongation GO:0007064 - mitotic sister chromatid cohesion
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 354
+	Hs
		517099 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC4_HUMAN (2-353): 5.88e-103: 309: 29.26
+	Hs
		517115 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC3_HUMAN (1-351): 1.57e-101: 305: 43.88
+	Dm
		572231 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q9VX15_DROME (2-353): 5.74e-97: 293: 22.73
+	Bt
		1100598 PCNA_BOVIN (1-258): 6.31e-110: 319: 35.52		Q29RS9_BOVIN (2-353): 1.66e-94: 286: 28.69
+	Bt
		985516 PCNA_BOVIN (1-258): 6.31e-110: 319: 35.52		RFC2_BOVIN (3-352): 5.79e-94: 285: 24.00
+	Dm
		572184 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q7KLW6_DROME (1-350): 2.94e-93: 285: 40.29
+	Hs
		517100 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC2_HUMAN (3-352): 1.34e-92: 282: 24.29
+	Hs
		517114 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC5_HUMAN (3-354): 7.94e-90: 274: 23.51
+	Dm
		572216 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q9VKW3_DROME (3-354): 1.87e-86: 265: 23.45
+	Sc
		550554 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC2_YEAST (2-351): 3.23e-97: 293: 25.63
+	Sc
		550541 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC3_YEAST (3-354): 1.08e-86: 266: 22.25
+	Sc
		550553 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC4_YEAST (3-349): 8.42e-84: 258: 22.19
+	Hs
		238255 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC4_HUMAN (2-353): 5.88e-103: 309: 29.26
+	Hs
		238259 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC3_HUMAN (1-351): 1.57e-101: 305: 43.88
+	Hs
		238258 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC5_HUMAN (3-354): 7.94e-90: 274: 23.51