HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: RFC4 (P40339)
Replication factor C subunit 4 (Replication factor C4) (Activator 1 37 kDa subunit)
Gene: RFC4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	8995429, 25450506, 20455582, 22197374
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~PCNA_C, AAA~PCNA_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006272 - leading strand elongation GO:0007064 - mitotic sister chromatid cohesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 323
+	Bt
		985516 PCNA_BOVIN (1-258): 6.31e-110: 319: 35.52		RFC2_BOVIN (7-318): 6.76e-85: 261: 60.83
+	Hs
		517099 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC4_HUMAN (4-318): 3.24e-84: 259: 34.36
+	Hs
		517100 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC2_HUMAN (7-318): 6.99e-84: 258: 60.19
+	Dm
		572216 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q9VKW3_DROME (2-322): 1.46e-83: 257: 36.81
+	Hs
		517114 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC5_HUMAN (2-316): 6.89e-82: 253: 34.80
+	Dm
		572231 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q9VX15_DROME (2-312): 3.89e-79: 246: 32.61
+	Bt
		1100598 PCNA_BOVIN (1-258): 6.31e-110: 319: 35.52		Q29RS9_BOVIN (4-318): 7.6e-78: 243: 34.26
+	Sc
		550541 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC3_YEAST (3-321): 1.39e-79: 247: 33.95
+	Hs
		517115 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC3_HUMAN (10-322): 5.12e-64: 207: 22.61
+	Hs
		517418 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		WRIP1_HUMAN (7-311): 2.49e-60: 205: 17.56
+	Sc
		550554 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC2_YEAST (8-319): 8.31e-77: 240: 34.24
+	Dm
		572184 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q7KLW6_DROME (10-322): 7.6e-61: 201: 21.45
+	Sc
		550539 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC5_YEAST (10-317): 1.76e-57: 190: 22.13
+	Hs
		238255 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC4_HUMAN (4-318): 3.24e-84: 259: 34.36
+	Hs
		238258 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC5_HUMAN (2-316): 6.89e-82: 253: 34.80
+	Hs
		238259 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC3_HUMAN (10-322): 5.12e-64: 207: 22.61
+	Sc
		550542 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC1_YEAST (11-227): 2.97e-15: 78.6: 26.72