HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: RFC2 (P40348)
Replication factor C subunit 2 (Replication factor C2) (Activator 1 41 kDa subunit)
Gene: RFC2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	8995429, 25450506, 16608854, 20455582, 22197374
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~PCNA_C, AAA~PCNA_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006272 - leading strand elongation GO:0006298 - mismatch repair GO:0007064 - mitotic sister chromatid cohesion
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 353
+	Hs
		517099 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC4_HUMAN (6-352): 2.16e-88: 271: 49.28
+	Hs
		517100 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC2_HUMAN (3-352): 4.51e-83: 258: 34.29
+	Bt
		985516 PCNA_BOVIN (1-258): 6.31e-110: 319: 35.52		RFC2_BOVIN (3-352): 1.04e-82: 256: 34.86
+	Bt
		1100598 PCNA_BOVIN (1-258): 6.31e-110: 319: 35.52		Q29RS9_BOVIN (6-352): 3.21e-80: 250: 47.01
+	Hs
		517114 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC5_HUMAN (7-350): 6.3e-81: 251: 33.62
+	Dm
		572231 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q9VX15_DROME (5-346): 4.06e-80: 250: 45.91
+	Dm
		572216 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q9VKW3_DROME (16-350): 1.03e-74: 235: 34.42
+	Hs
		517115 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		RFC3_HUMAN (26-353): 3.13e-67: 217: 23.41
+	Sc
		550541 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC3_YEAST (13-352): 1.36e-77: 243: 33.43
+	Hs
		517418 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		WRIP1_HUMAN (4-329): 2.57e-60: 206: 16.22
+	Dm
		572184 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		Q7KLW6_DROME (26-353): 4.12e-61: 202: 22.25
+	Sc
		550553 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC4_YEAST (24-353): 2.04e-67: 216: 34.24
+	Hs
		238255 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC4_HUMAN (6-352): 2.16e-88: 271: 49.28
+	Sc
		550539 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RFC5_YEAST (26-351): 1.98e-56: 189: 26.78
+	Hs
		238258 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC5_HUMAN (7-350): 6.3e-81: 251: 33.62
+	Hs
		238259 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		RFC3_HUMAN (26-353): 3.13e-67: 217: 23.41