HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: ID1 (P41134)
DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)
Gene: ID1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	25609649, 28514442, 9584154, 33961781, 32296183, 9242638, 21988832, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 667 Hs			1 155
+	Mm
		1141284 ITF2_MOUSE (1-667): 0: 918: 96.87		Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78
+	Mm
		781006 ITF2_MOUSE (1-667): 0: 918: 96.87		ID2_MOUSE (19-154): 3.1e-46: 148: 41.38
+	Mm
		780944 ITF2_MOUSE (1-667): 0: 918: 96.87		ID3_MOUSE (19-128): 8.16e-46: 147: 46.36
+	Hs
		551118 ITF2_HUMAN (1-667): 0: 908: 100.00		ID2_HUMAN (19-154): 3.39e-45: 146: 42.07
+	Hs
		551119 ITF2_HUMAN (1-667): 0: 908: 100.00		ID3_HUMAN (19-128): 1.94e-45: 146: 47.27
+	Hs
		551089 ITF2_HUMAN (1-667): 0: 908: 100.00		ID4_HUMAN (19-155): 1.46e-32: 114: 34.94
+	Hs
		780982 HTF4_HUMAN (3-667): 0: 783: 61.71		ID1_HUMAN (1-155): 1.17e-77: 229: 100.00
+	Mm
		1142448 HTF4_MOUSE (3-667): 0: 771: 59.22		Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78
+	Hs
		551478 TFE2_HUMAN (1-667): 0: 733: 49.71		ID1_HUMAN (1-155): 1.17e-77: 229: 100.00
+	Hs
		970599 HTF4_HUMAN (3-667): 0: 783: 61.71		ID2_HUMAN (19-154): 3.39e-45: 146: 42.07
+	Hs
		971137 HTF4_HUMAN (3-667): 0: 783: 61.71		ID3_HUMAN (19-128): 1.94e-45: 146: 47.27
+	Mm
		781007 HTF4_MOUSE (3-667): 0: 771: 59.22		ID2_MOUSE (19-154): 3.1e-46: 148: 41.38
+	Mm
		780945 HTF4_MOUSE (3-667): 0: 771: 59.22		ID3_MOUSE (19-128): 8.16e-46: 147: 46.36
+	Hs
		814913 HTF4_HUMAN (3-667): 0: 783: 61.71		ID4_HUMAN (19-155): 1.46e-32: 114: 34.94
+	Mm
		550178 TFE2_MOUSE (1-667): 0: 702: 47.69		ID1_MOUSE (15-142): 2.25e-63: 193: 89.84
+	Hs
		551502 TFE2_HUMAN (1-667): 0: 733: 49.71		ID2_HUMAN (19-154): 3.39e-45: 146: 42.07
+	Hs
		551503 TFE2_HUMAN (1-667): 0: 733: 49.71		ID3_HUMAN (19-128): 1.94e-45: 146: 47.27
+	Rn
		600264 TFE2_RAT (1-667): 0: 721: 47.39		ID3_RAT (19-128): 2.16e-45: 146: 46.36
+	Mm
		550183 TFE2_MOUSE (1-667): 0: 702: 47.69		ID3_MOUSE (19-128): 8.16e-46: 147: 46.36
+	Hs
		551480 TFE2_HUMAN (1-667): 0: 733: 49.71		ID4_HUMAN (19-155): 1.46e-32: 114: 34.94