HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: ID2 (Q02363)
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
Gene: ID2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	25609649, 9242638, 8576241, 9584154, 28514442, 33961781, 16549780
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0030154 - cell differentiation GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 667 Hs			1 134
+	Mm
		781006 ITF2_MOUSE (1-667): 0: 918: 96.87		ID2_MOUSE (1-134): 1.14e-70: 209: 98.51
+	Mm
		1141284 ITF2_MOUSE (1-667): 0: 918: 96.87		Q6GTZ3_MOUSE (15-133): 8.44e-45: 144: 46.83
+	Hs
		551084 ITF2_HUMAN (1-667): 0: 908: 100.00		ID1_HUMAN (14-133): 1.58e-45: 146: 45.39
+	Mm
		780944 ITF2_MOUSE (1-667): 0: 918: 96.87		ID3_MOUSE (1-133): 1.2e-41: 135: 38.41
+	Hs
		551119 ITF2_HUMAN (1-667): 0: 908: 100.00		ID3_HUMAN (1-133): 8.38e-44: 141: 39.13
+	Hs
		551089 ITF2_HUMAN (1-667): 0: 908: 100.00		ID4_HUMAN (33-109): 7.03e-31: 109: 54.12
+	Hs
		970599 HTF4_HUMAN (3-667): 0: 783: 61.71		ID2_HUMAN (1-134): 1.82e-70: 209: 100.00
+	Mm
		781007 HTF4_MOUSE (3-667): 0: 771: 59.22		ID2_MOUSE (1-134): 1.14e-70: 209: 98.51
+	Hs
		551502 TFE2_HUMAN (1-667): 0: 733: 49.71		ID2_HUMAN (1-134): 1.82e-70: 209: 100.00
+	Hs
		780982 HTF4_HUMAN (3-667): 0: 783: 61.71		ID1_HUMAN (14-133): 1.58e-45: 146: 45.39
+	Hs
		971137 HTF4_HUMAN (3-667): 0: 783: 61.71		ID3_HUMAN (1-133): 8.38e-44: 141: 39.13
+	Mm
		1142448 HTF4_MOUSE (3-667): 0: 771: 59.22		Q6GTZ3_MOUSE (15-133): 8.44e-45: 144: 46.83
+	Mm
		780945 HTF4_MOUSE (3-667): 0: 771: 59.22		ID3_MOUSE (1-133): 1.2e-41: 135: 38.41
+	Hs
		814913 HTF4_HUMAN (3-667): 0: 783: 61.71		ID4_HUMAN (33-109): 7.03e-31: 109: 54.12
+	Hs
		551478 TFE2_HUMAN (1-667): 0: 733: 49.71		ID1_HUMAN (14-133): 1.58e-45: 146: 45.39
+	Hs
		551503 TFE2_HUMAN (1-667): 0: 733: 49.71		ID3_HUMAN (1-133): 8.38e-44: 141: 39.13
+	Rn
		600264 TFE2_RAT (1-667): 0: 721: 47.39		ID3_RAT (1-133): 5.72e-42: 136: 38.41
+	Hs
		551480 TFE2_HUMAN (1-667): 0: 733: 49.71		ID4_HUMAN (33-109): 7.03e-31: 109: 54.12
+	Mm
		550178 TFE2_MOUSE (1-667): 0: 702: 47.69		ID1_MOUSE (15-123): 2.97e-41: 136: 50.00
+	Mm
		550183 TFE2_MOUSE (1-667): 0: 702: 47.69		ID3_MOUSE (1-133): 1.2e-41: 135: 38.41