HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: ID3 (Q02535)
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	25416956, 32296183, 8999959, 9242638, 25609649, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, experimental interaction detection, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 667 Hs			1 119
+	Mm
		780944 ITF2_MOUSE (1-667): 0: 918: 96.87		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Mm
		781006 ITF2_MOUSE (1-667): 0: 918: 96.87		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Mm
		1141284 ITF2_MOUSE (1-667): 0: 918: 96.87		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Hs
		551118 ITF2_HUMAN (1-667): 0: 908: 100.00		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		551084 ITF2_HUMAN (1-667): 0: 908: 100.00		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		551089 ITF2_HUMAN (1-667): 0: 908: 100.00		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		971137 HTF4_HUMAN (3-667): 0: 783: 61.71		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Mm
		780945 HTF4_MOUSE (3-667): 0: 771: 59.22		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		551503 TFE2_HUMAN (1-667): 0: 733: 49.71		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Hs
		970599 HTF4_HUMAN (3-667): 0: 783: 61.71		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		780982 HTF4_HUMAN (3-667): 0: 783: 61.71		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Rn
		600264 TFE2_RAT (1-667): 0: 721: 47.39		ID3_RAT (1-119): 3.74e-62: 187: 97.48
+	Mm
		781007 HTF4_MOUSE (3-667): 0: 771: 59.22		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Mm
		1142448 HTF4_MOUSE (3-667): 0: 771: 59.22		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Mm
		550183 TFE2_MOUSE (1-667): 0: 702: 47.69		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		814913 HTF4_HUMAN (3-667): 0: 783: 61.71		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		551502 TFE2_HUMAN (1-667): 0: 733: 49.71		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		551478 TFE2_HUMAN (1-667): 0: 733: 49.71		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Mm
		550178 TFE2_MOUSE (1-667): 0: 702: 47.69		ID1_MOUSE (3-100): 5.07e-42: 137: 46.60
+	Hs
		551480 TFE2_HUMAN (1-667): 0: 733: 49.71		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71