HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29374067, 36749823
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:1990907 - beta-catenin-TCF complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 772
+	Hs
		551124 ITF2_HUMAN (1-667): 0: 908: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		980851 HTF4_HUMAN (3-667): 0: 783: 61.71		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		551507 TFE2_HUMAN (1-667): 0: 733: 49.71		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		551506 TFE2_HUMAN (1-667): 0: 733: 49.71		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		551129 ITF2_HUMAN (1-667): 0: 908: 100.00		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		1022858 HTF4_HUMAN (3-667): 0: 783: 61.71		STRN3_HUMAN (119-770): 2.29e-48: 185: 10.91
+	Mm
		550260 TFE2_MOUSE (1-667): 0: 702: 47.69		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66
+	Hs
		1288259 HTF4_HUMAN (3-667): 0: 783: 61.71		SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52