HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: TAL2 (Q16559)
T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)
Gene: TAL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.875

Property	Details
Experiments	9242638, 25416956, 33961781
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 667 Hs			1 108
+	Mm
		603981 ITF2_MOUSE (1-667): 0: 918: 96.87		TAL1_MOUSE (1-104): 5.01e-27: 102: 47.37
+	Mm
		623784 ITF2_MOUSE (1-667): 0: 918: 96.87		MYF5_MOUSE (1-104): 5.45e-27: 101: 29.81
+	Mm
		1141281 ITF2_MOUSE (1-667): 0: 918: 96.87		HAND2_MOUSE (1-78): 3.15e-26: 98.5: 41.03
+	Mm
		644472 ITF2_MOUSE (1-667): 0: 918: 96.87		TWST1_MOUSE (2-66): 2.54e-25: 95.8: 53.85
+	Hs
		551140 ITF2_HUMAN (1-667): 0: 908: 100.00		NDF1_HUMAN (3-101): 2.18e-27: 104: 33.98
+	Hs
		551184 ITF2_HUMAN (1-667): 0: 908: 100.00		PTF1A_HUMAN (4-108): 9.86e-28: 104: 35.14
+	Hs
		551228 ITF2_HUMAN (1-667): 0: 908: 100.00		NGN1_HUMAN (2-108): 2.22e-27: 101: 31.53
+	Hs
		551272 ITF2_HUMAN (1-667): 0: 908: 100.00		NGN2_HUMAN (2-105): 1.98e-26: 100: 34.62
+	Hs
		551069 ITF2_HUMAN (1-667): 0: 908: 100.00		MYF6_HUMAN (2-107): 2.01e-26: 99.7: 23.59
+	Hs
		551106 ITF2_HUMAN (1-667): 0: 908: 100.00		HAND2_HUMAN (1-78): 3.15e-26: 98.5: 41.03
+	Hs
		551135 ITF2_HUMAN (1-667): 0: 908: 100.00		TCF15_HUMAN (3-103): 9.84e-26: 96.6: 37.74
+	Hs
		551151 ITF2_HUMAN (1-667): 0: 908: 100.00		TWST1_HUMAN (2-66): 6.25e-25: 94.7: 53.85
+	Hs
		524531 ITF2_HUMAN (1-667): 0: 908: 100.00		LYL1_HUMAN (1-108): 4.26e-24: 94.3: 47.22
+	Hs
		551060 ITF2_HUMAN (1-667): 0: 908: 100.00		TAL1_HUMAN (1-104): 8.18e-24: 94.3: 53.21
+	Hs
		551220 ITF2_HUMAN (1-667): 0: 908: 100.00		TWST2_HUMAN (2-66): 5.44e-25: 93.5: 52.31
+	Hs
		551254 ITF2_HUMAN (1-667): 0: 908: 100.00		FER3L_HUMAN (2-67): 1.03e-23: 90.4: 40.91
+	Hs
		551187 ITF2_HUMAN (1-667): 0: 908: 100.00		SCX_HUMAN (3-58): 1.76e-22: 88.5: 57.14
+	Hs
		551122 ITF2_HUMAN (1-667): 0: 908: 100.00		HEN2_HUMAN (9-58): 3.2e-22: 85.8: 66.00
+	Hs
		551121 ITF2_HUMAN (1-667): 0: 908: 100.00		HEN1_HUMAN (4-58): 6.58e-22: 85: 60.00
+	Hs
		330419 ITF2_HUMAN (1-667): 0: 908: 100.00		HAND1_HUMAN (3-65): 6.69e-21: 84.7: 47.62