HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: ASCL4 (Q6XD76)
Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)
Gene: ASCL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 667 Hs			1 172
+	Mm
		1141281 ITF2_MOUSE (1-667): 0: 918: 96.87		HAND2_MOUSE (6-171): 3.49e-30: 111: 21.18
+	Hs
		551093 ITF2_HUMAN (1-667): 0: 908: 100.00		ASCL1_HUMAN (16-170): 7.3e-31: 113: 34.59
+	Hs
		551184 ITF2_HUMAN (1-667): 0: 908: 100.00		PTF1A_HUMAN (19-171): 9.47e-30: 112: 26.35
+	Mm
		623784 ITF2_MOUSE (1-667): 0: 918: 96.87		MYF5_MOUSE (36-168): 1.65e-26: 102: 25.00
+	Mm
		1141301 ITF2_MOUSE (1-667): 0: 918: 96.87		ASCL3_MOUSE (7-143): 1.14e-26: 101: 36.55
+	Hs
		551106 ITF2_HUMAN (1-667): 0: 908: 100.00		HAND2_HUMAN (6-171): 3.49e-30: 111: 21.18
+	Mm
		644472 ITF2_MOUSE (1-667): 0: 918: 96.87		TWST1_MOUSE (28-167): 5.14e-26: 99: 21.43
+	Hs
		545931 ITF2_HUMAN (1-667): 0: 908: 100.00		MYOD1_HUMAN (5-166): 5.86e-28: 107: 27.98
+	Hs
		551179 ITF2_HUMAN (1-667): 0: 908: 100.00		FIGLA_HUMAN (13-161): 3.88e-28: 106: 26.32
+	Hs
		524531 ITF2_HUMAN (1-667): 0: 908: 100.00		LYL1_HUMAN (55-168): 6.19e-27: 104: 30.23
+	Hs
		551069 ITF2_HUMAN (1-667): 0: 908: 100.00		MYF6_HUMAN (13-170): 8.43e-27: 103: 22.42
+	Hs
		551183 ITF2_HUMAN (1-667): 0: 908: 100.00		BHA15_HUMAN (2-160): 2.86e-27: 103: 24.38
+	Hs
		546065 ITF2_HUMAN (1-667): 0: 908: 100.00		MYOG_HUMAN (12-167): 1.65e-26: 101: 23.72
+	Hs
		551135 ITF2_HUMAN (1-667): 0: 908: 100.00		TCF15_HUMAN (41-171): 2.06e-26: 101: 21.48
+	Hs
		210856 ITF2_HUMAN (1-667): 0: 908: 100.00		TCF21_HUMAN (29-139): 1.93e-26: 100: 22.52
+	Hs
		330419 ITF2_HUMAN (1-667): 0: 908: 100.00		HAND1_HUMAN (3-170): 3.87e-26: 100: 20.81
+	Hs
		551155 ITF2_HUMAN (1-667): 0: 908: 100.00		TAL2_HUMAN (73-169): 4.26e-27: 99: 32.04
+	Hs
		551122 ITF2_HUMAN (1-667): 0: 908: 100.00		HEN2_HUMAN (1-129): 3.36e-26: 98.4: 25.37
+	Hs
		551060 ITF2_HUMAN (1-667): 0: 908: 100.00		TAL1_HUMAN (57-161): 7.57e-22: 91.5: 30.28
+	Mm
		603981 ITF2_MOUSE (1-667): 0: 918: 96.87		TAL1_MOUSE (56-131): 2.67e-10: 59.5: 36.25