HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: ID1 (P41134)
DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)
Gene: ID1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	26496610, 9242638, 35440621, 32296183, 19125693, 22354994, unassigned1304, 10915743
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 155
+	Mm
		550218 TFE2_MOUSE (1-654): 0: 861: 82.50		Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78
+	Mm
		550178 TFE2_MOUSE (1-654): 0: 861: 82.50		ID1_MOUSE (15-142): 2.25e-63: 193: 89.84
+	Hs
		551502 TFE2_HUMAN (1-654): 0: 907: 100.00		ID2_HUMAN (19-154): 3.39e-45: 146: 42.07
+	Hs
		551503 TFE2_HUMAN (1-654): 0: 907: 100.00		ID3_HUMAN (19-128): 1.94e-45: 146: 47.27
+	Rn
		600264 TFE2_RAT (1-654): 0: 879: 81.83		ID3_RAT (19-128): 2.16e-45: 146: 46.36
+	Hs
		551480 TFE2_HUMAN (1-654): 0: 907: 100.00		ID4_HUMAN (19-155): 1.46e-32: 114: 34.94
+	Mm
		550184 TFE2_MOUSE (1-654): 0: 861: 82.50		ID2_MOUSE (19-154): 3.1e-46: 148: 41.38
+	Mm
		550183 TFE2_MOUSE (1-654): 0: 861: 82.50		ID3_MOUSE (19-128): 8.16e-46: 147: 46.36
+	Hs
		780982 HTF4_HUMAN (3-654): 0: 763: 49.35		ID1_HUMAN (1-155): 1.17e-77: 229: 100.00
+	Hs
		551084 ITF2_HUMAN (1-654): 0: 758: 50.07		ID1_HUMAN (1-155): 1.17e-77: 229: 100.00
+	Mm
		1141284 ITF2_MOUSE (1-654): 0: 770: 50.50		Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78
+	Mm
		1142448 HTF4_MOUSE (3-654): 0: 760: 47.16		Q6GTZ3_MOUSE (15-155): 1.41e-70: 211: 90.78
+	Mm
		781006 ITF2_MOUSE (1-654): 0: 770: 50.50		ID2_MOUSE (19-154): 3.1e-46: 148: 41.38
+	Mm
		780944 ITF2_MOUSE (1-654): 0: 770: 50.50		ID3_MOUSE (19-128): 8.16e-46: 147: 46.36
+	Hs
		970599 HTF4_HUMAN (3-654): 0: 763: 49.35		ID2_HUMAN (19-154): 3.39e-45: 146: 42.07
+	Hs
		971137 HTF4_HUMAN (3-654): 0: 763: 49.35		ID3_HUMAN (19-128): 1.94e-45: 146: 47.27
+	Mm
		781007 HTF4_MOUSE (3-654): 0: 760: 47.16		ID2_MOUSE (19-154): 3.1e-46: 148: 41.38
+	Mm
		780945 HTF4_MOUSE (3-654): 0: 760: 47.16		ID3_MOUSE (19-128): 8.16e-46: 147: 46.36
+	Hs
		814913 HTF4_HUMAN (3-654): 0: 763: 49.35		ID4_HUMAN (19-155): 1.46e-32: 114: 34.94
+	Hs
		551089 ITF2_HUMAN (1-654): 0: 758: 50.07		ID4_HUMAN (19-155): 1.46e-32: 114: 34.94