HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: ID3 (Q02535)
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	25416956, 9525934, 9242638, 35440621, 32296183, 22354994, 10915743, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0043425 - bHLH transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 119
+	Rn
		600264 TFE2_RAT (1-654): 0: 879: 81.83		ID3_RAT (1-119): 3.74e-62: 187: 97.48
+	Mm
		550183 TFE2_MOUSE (1-654): 0: 861: 82.50		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		551502 TFE2_HUMAN (1-654): 0: 907: 100.00		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		551478 TFE2_HUMAN (1-654): 0: 907: 100.00		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		551480 TFE2_HUMAN (1-654): 0: 907: 100.00		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Mm
		550178 TFE2_MOUSE (1-654): 0: 861: 82.50		ID1_MOUSE (3-100): 5.07e-42: 137: 46.60
+	Mm
		550184 TFE2_MOUSE (1-654): 0: 861: 82.50		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Mm
		550218 TFE2_MOUSE (1-654): 0: 861: 82.50		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Mm
		780944 ITF2_MOUSE (1-654): 0: 770: 50.50		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		971137 HTF4_HUMAN (3-654): 0: 763: 49.35		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Mm
		780945 HTF4_MOUSE (3-654): 0: 760: 47.16		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Mm
		781006 ITF2_MOUSE (1-654): 0: 770: 50.50		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Mm
		1141284 ITF2_MOUSE (1-654): 0: 770: 50.50		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Hs
		970599 HTF4_HUMAN (3-654): 0: 763: 49.35		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		780982 HTF4_HUMAN (3-654): 0: 763: 49.35		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Mm
		781007 HTF4_MOUSE (3-654): 0: 760: 47.16		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Hs
		551084 ITF2_HUMAN (1-654): 0: 758: 50.07		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Mm
		1142448 HTF4_MOUSE (3-654): 0: 760: 47.16		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Hs
		814913 HTF4_HUMAN (3-654): 0: 763: 49.35		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		551089 ITF2_HUMAN (1-654): 0: 758: 50.07		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71