HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: MESP1 (Q9BRJ9)
Mesoderm posterior protein 1 (Class C basic helix-loop-helix protein 5) (bHLHc5)
Gene: MESP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

The method score is based on:

Property	Details
Experiments	36413948, 26694203
Identification Methods	two hybrid, affinity chromatography technology, gal4 vp16 complementation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity and 4 others more... GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	654
Hs

1	268

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024