HitPredict

Interactor 1: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2871 Hs			1 530
+	Hs
		368926 DESP_HUMAN (1-2871): 0: 818: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377068 DESP_HUMAN (1-2871): 0: 818: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		414434 DESP_HUMAN (1-2871): 0: 818: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487105 DESP_HUMAN (1-2871): 0: 818: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		828606 CENPF_HUMAN (11-1800): 6.64e-55: 215: 10.64		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1068618 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1034609 GOGA4_HUMAN (1137-2522): 1.45e-40: 168: 9.60		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1045473 SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		234256 PEPL_HUMAN (1428-2565): 6.62e-28: 126: 14.08		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269456 AKAP9_HUMAN (1336-2427): 2.28e-27: 125: 8.91		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369641 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369786 CROCC_HUMAN (1122-2526): 6.09e-41: 169: 10.95		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		974119 DYST_HUMAN (91-2218): 3.51e-25: 118: 10.10		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269900 MYH13_HUMAN (1490-2045): 1e-24: 116: 13.84		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		522631 MYH7_HUMAN (38-718): 1.99e-21: 105: 8.44		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1059246 GOGB1_HUMAN (1530-2529): 4.77e-20: 101: 9.08		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369568 SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369446 DYST_HUMAN (91-2218): 3.51e-25: 118: 10.10		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369619 GOGB1_HUMAN (1530-2529): 4.77e-20: 101: 9.08		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377795 MYH2_HUMAN (1590-2502): 7.34e-35: 149: 11.14		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64