HitPredict

Interactor 1: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29844126
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2871 Hs			1 2517
+	Hs
		885297 EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		963398 SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		551635 DESP_HUMAN (1-2871): 0: 818: 100.00		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		551790 DESP_HUMAN (1-2871): 0: 818: 100.00		TITIN_HUMAN (609-1544): 3.51e-09: 65.2: 9.85
+	Hs
		818070 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		234198 PEPL_HUMAN (1428-2565): 6.62e-28: 126: 14.08		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Mm
		82750 B9EKJ1_MOUSE (235-2081): 2.53e-27: 124: 8.99		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Hs
		818318 EVPL_HUMAN (121-1188): 7.71e-17: 90.4: 9.26		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		817925 SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		818611 MACF1_HUMAN (1987-2820): 9.45e-10: 67.2: 12.38		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		1068702 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		SRRM2_HUMAN (291-1369): 4.76e-10: 67.9: 8.34
+	Hs
		944680 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		MAP1A_HUMAN (763-2517): 4.52e-09: 64.4: 8.00
+	Mm
		561172 SPTN1_MOUSE (47-1140): 2.07e-22: 108: 9.76		ANK2_MOUSE (626-2418): 3.15e-17: 91.5: 8.46
+	Hs
		1045443 SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67		MICA3_HUMAN (2116-2494): 3.95e-09: 64.7: 11.35
+	Hs
		965102 SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67		ANK2_HUMAN (535-2225): 4.48e-09: 64.6: 9.78
+	Hs
		885330 EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71		SRRM2_HUMAN (291-1369): 4.76e-10: 67.9: 8.34
+	Hs
		963451 SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93		SRRM2_HUMAN (291-1369): 4.76e-10: 67.9: 8.34
+	Hs
		963358 SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93		MICA3_HUMAN (2116-2494): 3.95e-09: 64.7: 11.35
+	Hs
		963292 SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93		ANK2_HUMAN (535-2225): 4.48e-09: 64.6: 9.78
+	Hs
		965174 MACF1_HUMAN (1987-2820): 9.45e-10: 67.2: 12.38		ANK2_HUMAN (535-2225): 4.48e-09: 64.6: 9.78