HitPredict

Interactor 1: RFA2 (P15927)
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
Gene: RPA2

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20679368, 37827155
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006260 - DNA replication GO:0031571 - mitotic G1 DNA damage checkpoint signaling
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 270 Hs			1 298
+	Hs
		414714 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		552508 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		552251 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		414898 RFA4_HUMAN (1-268): 6.87e-96: 283: 45.56		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Ca
		793056 Q59Z33_CANAL (4-264): 1.49e-64: 204: 26.37		CDK1_CANAL (1-286): 1.39e-136: 390: 65.40