HitPredict

Interactor 1: RFA2 (P15927)
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
Gene: RPA2

Interactor 2: RIF1 (Q5UIP0)
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Gene: RIF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	37827155, 16169070, 20711169
Identification Methods	proximity labelling technology, two hybrid pooling approach, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035861 - site of double-strand break
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 270 Hs			1 2472
+	Hs
		1026437 RFA4_HUMAN (1-268): 6.87e-96: 283: 45.56		RIF1_HUMAN (1-2472): 0: 1703: 100.00
+	Hs
		553066 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		RBBP6_HUMAN (1213-2173): 1.39e-26: 122: 9.31
+	Hs
		552957 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		NIPBL_HUMAN (948-1837): 3.15e-19: 98.1: 12.40
+	Hs
		552176 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		MAP1B_HUMAN (745-2457): 3e-18: 94.6: 8.05
+	Hs
		553508 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		MINT_HUMAN (779-2447): 5.2e-18: 94.2: 7.95
+	Hs
		552728 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		MDC1_HUMAN (958-2272): 4.95e-18: 93.9: 10.74
+	Hs
		60146 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		XIRP2_HUMAN (983-2380): 1.01e-11: 73.4: 8.38