HitPredict

Interactor 1: MUC1 (P15941)
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Gene: MUC1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	7664271, 20936779
Identification Methods	pull down, affinity chromatography technology, two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 217
+	Hs
		411582 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337335 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		433560 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522749 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		924808 MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924760 PRG4_HUMAN (2-588): 4.78e-12: 72.9: 12.27		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924909 BICRA_HUMAN (23-1109): 2.84e-09: 63.9: 11.04		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557777 MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		297808 K0754_HUMAN (634-1098): 3.29e-23: 109: 14.17		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		557809 BICRA_HUMAN (23-1109): 2.84e-09: 63.9: 11.04		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		152571 KMT2D_HUMAN (572-1064): 9.35e-09: 62.4: 12.35		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		522986 NCOA6_HUMAN (10-1050): 3.47e-16: 86.7: 9.70		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		434084 SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523177 BICRA_HUMAN (23-1109): 2.84e-09: 63.9: 11.04		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58