HitPredict

Interactor 1: SPTN1 (P16086)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)
Gene: Sptan1

Interactor 2: TANC1 (Q6F6B3)
Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1)
Gene: TANC1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15673434
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1
Common GO terms	GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Rn			1 1849
+	Dm
		114363 ACTN_DROME (1864-2470): 1.55e-77: 280: 30.27		M9PC91_DROME (356-1427): 0: 734: 41.94
+	Hs
		360612 SPTA1_HUMAN (1-2472): 1.19e-149: 522: 54.60		ANK1_HUMAN (706-1645): 3.71e-137: 474: 15.61
+	Hs
		506803 SPTB1_HUMAN (2-1629): 2.11e-61: 236: 19.06		ANK1_HUMAN (706-1645): 3.71e-137: 474: 15.61
+	Rn
		251022 PLEC_RAT (1-1363): 4.78e-44: 180: 9.97		ANK3_RAT (696-1842): 8.85e-128: 449: 15.03
+	Hs
		1021399 SPTN1_HUMAN (3-2098): 6.08e-80: 297: 22.88		ANK3_HUMAN (895-1538): 1.75e-88: 325: 19.68
+	Hs
		965102 SPTN1_HUMAN (3-2098): 6.08e-80: 297: 22.88		ANK2_HUMAN (894-1472): 2.37e-88: 324: 21.81
+	Hs
		556695 SPTB2_HUMAN (1-521): 1.54e-19: 99: 31.55		ANK1_HUMAN (706-1645): 3.71e-137: 474: 15.61
+	Mm
		103598 Q3UGX2_MOUSE (2-1626): 2.03e-59: 230: 19.17		ANK3_MOUSE (895-1538): 8.16e-93: 337: 19.82
+	Mm
		82740 B9EKJ1_MOUSE (3-1701): 3.42e-48: 193: 20.84		ANK3_MOUSE (895-1538): 8.16e-93: 337: 19.82
+	Hs
		1021404 PLEC_HUMAN (1-1272): 1.62e-38: 161: 9.94		ANK3_HUMAN (895-1538): 1.75e-88: 325: 19.68
+	Hs
		1021458 SPTN4_HUMAN (961-2380): 1.24e-29: 132: 14.51		ANK3_HUMAN (895-1538): 1.75e-88: 325: 19.68
+	Hs
		965174 MACF1_HUMAN (803-2418): 2.95e-27: 124: 10.15		ANK2_HUMAN (894-1472): 2.37e-88: 324: 21.81
+	Hs
		164611 SPTN2_HUMAN (1652-2318): 6.59e-23: 110: 19.85		ANK3_HUMAN (895-1538): 1.75e-88: 325: 19.68
+	Hs
		164604 SPTN2_HUMAN (1652-2318): 6.59e-23: 110: 19.85		ANK2_HUMAN (894-1472): 2.37e-88: 324: 21.81
+	Mm
		57440 PLEC_MOUSE (1-1313): 1.2e-40: 169: 12.79		A2AM57_MOUSE (613-1093): 7.48e-61: 231: 13.72
+	Mm
		57416 Q6S385_MOUSE (821-2464): 3.36e-31: 137: 7.84		A2AM57_MOUSE (613-1093): 7.48e-61: 231: 13.72
+	Hs
		862037 SPTN1_HUMAN (3-2098): 6.08e-80: 297: 22.88		DAPK1_HUMAN (1127-1225): 1.06e-09: 65.9: 34.34
+	Mm
		561172 SPTN1_MOUSE (3-1701): 3.36e-48: 193: 21.71		ANK2_MOUSE (1278-1849): 1.01e-09: 66.2: 8.19
+	Hs
		862098 CP250_HUMAN (1-1084): 1.84e-39: 164: 10.69		DAPK1_HUMAN (1127-1225): 1.06e-09: 65.9: 34.34
+	Hs
		164586 SPTN2_HUMAN (1652-2318): 6.59e-23: 110: 19.85		DAPK1_HUMAN (1127-1225): 1.06e-09: 65.9: 34.34