HitPredict

Interactor 1: FGFR1 (P16092)
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FRS2 (Q8C180)
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (FRS2-alpha) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Gene: FRS2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	17901128, 15513912
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001759 - organ induction GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0050678 - regulation of epithelial cell proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Mm			1 508
+	Hs
		508122 FGFR1_HUMAN (1-822): 0: 847: 98.42		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		601554 FGFR2_HUMAN (1-812): 0: 787: 71.26		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		207292 FGFR1_HUMAN (1-822): 0: 847: 98.42		FRS3_HUMAN (1-508): 1.11e-167: 484: 47.32
+	Mm
		555270 FGFR1_MOUSE (1-822): 0: 849: 100.00		FRS3_MOUSE (1-508): 8.35e-160: 464: 47.79
+	Hs
		609443 FGFR3_HUMAN (1-808): 0: 721: 61.93		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		608060 FGFR4_HUMAN (30-807): 0: 649: 56.39		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		872680 EPHA4_HUMAN (3-821): 0: 634: 18.53		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		1081545 NTRK3_HUMAN (111-762): 9.47e-171: 516: 23.30		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		1083873 NTRK2_HUMAN (58-762): 4.26e-161: 490: 22.52		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		385225 NTRK1_HUMAN (122-762): 2.06e-154: 472: 26.10		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		434249 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		FRS2_HUMAN (1-508): 0: 578: 95.87
+	Hs
		203204 FGFR1_HUMAN (1-822): 0: 847: 98.42		SYNJ1_HUMAN (144-504): 6.41e-09: 60.8: 12.34
+	Mm
		1101896 NTRK3_MOUSE (111-762): 6.07e-175: 526: 24.08		DOK6_MOUSE (13-186): 3.8e-65: 216: 22.16
+	Hs
		1081513 NTRK3_HUMAN (111-762): 9.47e-171: 516: 23.30		DOK6_HUMAN (13-186): 2.46e-64: 213: 22.16
+	Hs
		434273 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK1_HUMAN (14-333): 3.17e-88: 280: 20.24
+	Hs
		434219 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK6_HUMAN (13-186): 2.46e-64: 213: 22.16
+	Hs
		235038 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK2_HUMAN (20-269): 2.23e-62: 211: 21.27
+	Hs
		434248 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK4_HUMAN (13-191): 1.49e-57: 196: 16.33
+	Hs
		434299 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK5_HUMAN (13-177): 1.5e-57: 195: 17.71
+	Mm
		452182 CSF1R_MOUSE (464-769): 9.31e-78: 273: 42.11		DOK1_MOUSE (14-332): 1.04e-87: 279: 17.94