HitPredict

Interactor 1: FGFR1 (P16092)
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FGF21 (Q9JJN1)
Fibroblast growth factor 21 (FGF-21)
Gene: FGF21

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	17452648
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FGF~I-set
Common GO terms	GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0090080 - positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Mm			1 210
+	Hs
		320638 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF19_HUMAN (4-208): 1.11e-70: 216: 34.72
+	Mm
		555272 FGFR1_MOUSE (1-822): 0: 849: 100.00		FGF23_MOUSE (11-210): 2.65e-69: 213: 34.31
+	Hs
		508186 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF23_HUMAN (11-210): 8.45e-70: 214: 32.04
+	Mm
		555263 FGFR1_MOUSE (1-822): 0: 849: 100.00		FGF9_MOUSE (31-185): 1.32e-57: 182: 26.51
+	Hs
		507874 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF9_HUMAN (31-185): 9.04e-58: 182: 26.51
+	Hs
		499375 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF6_HUMAN (41-168): 1.47e-50: 164: 31.82
+	Hs
		181657 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF10_HUMAN (38-168): 2.91e-49: 161: 27.86
+	Hs
		441802 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF4_HUMAN (14-168): 1.48e-48: 159: 30.82
+	Hs
		507813 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF3_HUMAN (27-204): 3.76e-48: 159: 25.25
+	Hs
		225915 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF17_HUMAN (27-193): 6.61e-46: 152: 19.89
+	Mm
		549545 FGFR1_MOUSE (1-822): 0: 849: 100.00		FGF2_MOUSE (24-168): 1.3e-45: 150: 28.67
+	Hs
		447013 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF2_HUMAN (23-168): 2.41e-44: 151: 28.48
+	Hs
		507815 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF5_HUMAN (46-185): 1.9e-43: 148: 26.97
+	Hs
		399128 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF1_HUMAN (39-170): 5.41e-44: 146: 30.22
+	Hs
		507927 FGFR1_HUMAN (1-822): 0: 847: 98.42		FGF8_HUMAN (46-185): 1.15e-42: 145: 17.12
+	Hs
		181659 FGFR2_HUMAN (1-812): 0: 787: 71.26		FGF10_HUMAN (38-168): 2.91e-49: 161: 27.86
+	Hs
		441808 FGFR2_HUMAN (1-812): 0: 787: 71.26		FGF4_HUMAN (14-168): 1.48e-48: 159: 30.82
+	Hs
		225918 FGFR2_HUMAN (1-812): 0: 787: 71.26		FGF17_HUMAN (27-193): 6.61e-46: 152: 19.89
+	Hs
		447019 FGFR2_HUMAN (1-812): 0: 787: 71.26		FGF2_HUMAN (23-168): 2.41e-44: 151: 28.48
+	Hs
		399132 FGFR2_HUMAN (1-812): 0: 787: 71.26		FGF1_HUMAN (39-170): 5.41e-44: 146: 30.22