HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: DNLI3 (P49916)
DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)
Gene: LIG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000724 - double-strand break repair via homologous recombination GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006302 - double-strand break repair
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 1009
+	Hs
		391601 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		DNLI3_HUMAN (1-1009): 0: 1373: 100.00
+	Hs
		470301 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		DNLI3_HUMAN (1-1009): 0: 1373: 100.00
+	Hs
		836737 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		DNLI3_HUMAN (1-1009): 0: 1373: 100.00
+	Sc
		392219 H2A1_YEAST (16-142): 1.37e-53: 166: 75.59		DNLI4_YEAST (284-934): 9.79e-157: 489: 18.73