Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX
Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 0.60 | 0.764 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28242625, 32518374, 30673298, 15201865, 12607005, 21676867, 14519663, 30598506, 21622030, 21293379, 20159462, 19234442, 16377563, 18583988 |
| Identification Methods | affinity chromatography technology, pull down, unspecified method, fluorescence polarization spectroscopy, surface plasmon resonance, anti tag coimmunoprecipitation, coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography, enzymatic footprinting |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035861 - site of double-strand break |
| Homologous interactions | 17 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
